Drug interactions
Tamoxifen + Vilazodone
Severity: Minor
Tamoxifen and Vilazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen is a weak CYP3A4 inhibitor and may modestly increase vilazodone exposure. Any change is unlikely to be clinically important for most patients.
What this interaction means in plain words
Tamoxifen and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tamoxifen belongs to Endocrine; Vilazodone belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4-mediated vilazodone metabolism by tamoxifen.
What to do
No dose adjustment is usually needed; watch for increased serotonergic adverse effects such as nausea, diarrhea or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Tamoxifen with Vilazodone?
MediHelp rates the interaction as minor. Tamoxifen and Vilazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tamoxifen is a weak CYP3A4 inhibitor and may modestly increase vilazodone exposure. Any change is unlikely to be clinically important for most patients.
How serious is the interaction between Tamoxifen and Vilazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for increased serotonergic adverse effects such as nausea, diarrhea or insomnia.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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