Drug interactions
Tamsulosin + Trazodone
Severity: Moderate
Tamsulosin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has alpha-1 blocking activity and commonly causes orthostatic hypotension, which may add to tamsulosin's effect. Trazodone is also a CYP2D6 substrate, with only minor inhibitory potential.
What this interaction means in plain words
Tamsulosin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tamsulosin belongs to Genitourinary; Trazodone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic blockade, with possible minor CYP2D6 competition.
What to do
Monitor for orthostatic hypotension and falls, particularly in older patients. Reduce the dose of either drug if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Tamsulosin with Trazodone?
MediHelp rates the interaction as moderate. Tamsulosin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has alpha-1 blocking activity and commonly causes orthostatic hypotension, which may add to tamsulosin's effect. Trazodone is also a CYP2D6 substrate, with only minor inhibitory potential.
How serious is the interaction between Tamsulosin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and falls, particularly in older patients. Reduce the dose of either drug if symptomatic.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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