Drug interactions
Tazemetostat + Upadacitinib
Severity: Minor
Tazemetostat and Upadacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak to moderate CYP3A4 inducer and may lower upadacitinib exposure. Reduced exposure could weaken disease control in the treated inflammatory condition.
What this interaction means in plain words
Tazemetostat and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tazemetostat belongs to Miscellaneous; Upadacitinib belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 increases the metabolic clearance of upadacitinib.
What to do
Monitor for loss of upadacitinib efficacy. Dose changes are generally not needed unless response is clearly lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Upadacitinib?
MediHelp rates the interaction as minor. Tazemetostat and Upadacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak to moderate CYP3A4 inducer and may lower upadacitinib exposure. Reduced exposure could weaken disease control in the treated inflammatory condition.
How serious is the interaction between Tazemetostat and Upadacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of upadacitinib efficacy. Dose changes are generally not needed unless response is clearly lost.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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