Drug interactions
Tazemetostat + Voriconazole
Severity: Major
Tazemetostat and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is metabolized mainly by CYP3A4, and voriconazole increases its exposure. This may increase the risk of tazemetostat adverse effects such as hematologic toxicity and fatigue.
What this interaction means in plain words
Tazemetostat and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tazemetostat belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of tazemetostat.
What to do
Substitute a non-CYP3A4-inhibiting antifungal if possible. If not, reduce the tazemetostat dose per labeling and monitor blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Tazemetostat with Voriconazole?
MediHelp rates the interaction as major. Tazemetostat and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tazemetostat is metabolized mainly by CYP3A4, and voriconazole increases its exposure. This may increase the risk of tazemetostat adverse effects such as hematologic toxicity and fatigue.
How serious is the interaction between Tazemetostat and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Substitute a non-CYP3A4-inhibiting antifungal if possible. If not, reduce the tazemetostat dose per labeling and monitor blood counts.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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