Drug interactions
Tecovirimat + Voriconazole
Severity: Moderate
Tecovirimat and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak inhibitor of CYP2C19 and a weak inducer of CYP3A4, which could modestly change voriconazole concentrations in opposing directions. The net effect is unpredictable and may alter voriconazole efficacy or toxicity.
What this interaction means in plain words
Tecovirimat and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tecovirimat belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Tecovirimat weakly inhibits CYP2C19 and weakly induces CYP3A4, both involved in voriconazole metabolism.
What to do
Monitor voriconazole trough concentrations and clinical response, and watch for toxicity or loss of antifungal effect during and after tecovirimat therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Tecovirimat with Voriconazole?
MediHelp rates the interaction as moderate. Tecovirimat and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat is a weak inhibitor of CYP2C19 and a weak inducer of CYP3A4, which could modestly change voriconazole concentrations in opposing directions. The net effect is unpredictable and may alter voriconazole efficacy or toxicity.
How serious is the interaction between Tecovirimat and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough concentrations and clinical response, and watch for toxicity or loss of antifungal effect during and after tecovirimat therapy.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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