Drug interactions
Tedizolid + Tranylcypromine
Severity: Major
Tedizolid and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tedizolid is a weak reversible MAO inhibitor and tranylcypromine is an irreversible nonselective MAOI. Combined use could raise the risk of serotonin toxicity or hypertensive reactions. Tedizolid was not studied with MAOIs in clinical trials, and the related oxazolidinone linezolid is contraindicated with them.
What this interaction means in plain words
Tedizolid and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tedizolid belongs to Anti Bacterial; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive monoamine oxidase inhibition leading to pharmacodynamic potentiation of serotonergic and pressor effects.
What to do
Avoid the combination where possible and choose a different antibacterial. If it is unavoidable, monitor closely for serotonin syndrome and blood pressure elevation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Tedizolid with Tranylcypromine?
MediHelp rates the interaction as major. Tedizolid and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tedizolid is a weak reversible MAO inhibitor and tranylcypromine is an irreversible nonselective MAOI. Combined use could raise the risk of serotonin toxicity or hypertensive reactions. Tedizolid was not studied with MAOIs in clinical trials, and the related oxazolidinone linezolid is contraindicated with them.
How serious is the interaction between Tedizolid and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a different antibacterial. If it is unavoidable, monitor closely for serotonin syndrome and blood pressure elevation.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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