Drug interactions
Temozolomide + Valproic acid
Severity: Moderate
Temozolomide and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproic acid may modestly reduce temozolomide clearance, and both drugs can contribute to thrombocytopenia and other cytopenias. Patients may therefore be at higher risk of myelosuppression.
What this interaction means in plain words
Temozolomide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temozolomide belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Modest reduction in temozolomide clearance plus additive myelosuppression.
What to do
Monitor blood counts, especially platelets and neutrophils, and reduce or delay temozolomide dosing if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Temozolomide
Frequently asked questions
Can I take Temozolomide with Valproic acid?
MediHelp rates the interaction as moderate. Temozolomide and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valproic acid may modestly reduce temozolomide clearance, and both drugs can contribute to thrombocytopenia and other cytopenias. Patients may therefore be at higher risk of myelosuppression.
How serious is the interaction between Temozolomide and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, especially platelets and neutrophils, and reduce or delay temozolomide dosing if cytopenias develop.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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