Drug interactions
Temsirolimus + Ustekinumab
Severity: Major
Temsirolimus and Ustekinumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are immunosuppressive, so concurrent use may raise the risk of serious infection. Temsirolimus is given to patients with advanced cancer who may already be vulnerable to infection.
What this interaction means in plain words
Temsirolimus and Ustekinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Temsirolimus belongs to Oncology; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression through IL-12/23 blockade and mTOR inhibition.
What to do
Avoid the combination if alternatives exist; if both are required, screen for latent infection and monitor closely for infection, interrupting ustekinumab if a serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Ustekinumab?
MediHelp rates the interaction as major. Temsirolimus and Ustekinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are immunosuppressive, so concurrent use may raise the risk of serious infection. Temsirolimus is given to patients with advanced cancer who may already be vulnerable to infection.
How serious is the interaction between Temsirolimus and Ustekinumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if alternatives exist; if both are required, screen for latent infection and monitor closely for infection, interrupting ustekinumab if a serious infection develops.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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