Drug interactions
Temsirolimus + Venetoclax
Severity: Moderate
Temsirolimus and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venetoclax inhibits P-gp and may raise temsirolimus exposure, especially through increased intestinal absorption. Higher concentrations may worsen mTOR-related adverse effects, and both drugs can cause cytopenias.
What this interaction means in plain words
Temsirolimus and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Venetoclax belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by venetoclax, increasing temsirolimus exposure.
What to do
Monitor blood counts and temsirolimus toxicity closely, and reduce the temsirolimus dose if adverse effects appear. Separating dosing is of limited use because temsirolimus is given intravenously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Temsirolimus with Venetoclax?
MediHelp rates the interaction as moderate. Temsirolimus and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venetoclax inhibits P-gp and may raise temsirolimus exposure, especially through increased intestinal absorption. Higher concentrations may worsen mTOR-related adverse effects, and both drugs can cause cytopenias.
How serious is the interaction between Temsirolimus and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and temsirolimus toxicity closely, and reduce the temsirolimus dose if adverse effects appear. Separating dosing is of limited use because temsirolimus is given intravenously.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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