Drug interactions
Temsirolimus + Verapamil
Severity: Moderate
Temsirolimus and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of mTOR-related toxicity. Intravenous temsirolimus is less affected by gut metabolism, so the effect may be smaller than with oral mTOR inhibitors.
What this interaction means in plain words
Temsirolimus and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of temsirolimus and its metabolite sirolimus.
What to do
Prefer a non-inhibiting alternative to verapamil where possible. If coadministered, monitor for stomatitis, cytopenias, hyperglycemia, lipid abnormalities and pneumonitis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Verapamil?
MediHelp rates the interaction as moderate. Temsirolimus and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase exposure to temsirolimus and its active metabolite sirolimus, raising the risk of mTOR-related toxicity. Intravenous temsirolimus is less affected by gut metabolism, so the effect may be smaller than with oral mTOR inhibitors.
How serious is the interaction between Temsirolimus and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inhibiting alternative to verapamil where possible. If coadministered, monitor for stomatitis, cytopenias, hyperglycemia, lipid abnormalities and pneumonitis.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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