Drug interactions
Temsirolimus + Voclosporin
Severity: Moderate
Temsirolimus and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a CYP3A4 and P-gp inhibitor and may raise temsirolimus and sirolimus exposure. Both agents are immunosuppressive, so combined use increases infection risk and may add nephrotoxicity.
What this interaction means in plain words
Temsirolimus and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Voclosporin inhibits P-gp and CYP3A4, reducing efflux and metabolism of temsirolimus; pharmacodynamic immunosuppression is additive.
What to do
Monitor for temsirolimus toxicity, infection and renal function; reduce the temsirolimus dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Temsirolimus with Voclosporin?
MediHelp rates the interaction as moderate. Temsirolimus and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin is a CYP3A4 and P-gp inhibitor and may raise temsirolimus and sirolimus exposure. Both agents are immunosuppressive, so combined use increases infection risk and may add nephrotoxicity.
How serious is the interaction between Temsirolimus and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity, infection and renal function; reduce the temsirolimus dose if adverse effects occur.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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