Drug interactions
Temsirolimus + Voxelotor
Severity: Moderate
Temsirolimus and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can moderately inhibit CYP3A4 and may increase exposure to temsirolimus and sirolimus. This could heighten mTOR-related toxicity.
What this interaction means in plain words
Temsirolimus and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 metabolism of temsirolimus by voxelotor.
What to do
Monitor for temsirolimus toxicity such as stomatitis, cytopenias, hyperglycemia and pneumonitis, and consider a dose reduction if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Temsirolimus with Voxelotor?
MediHelp rates the interaction as moderate. Temsirolimus and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can moderately inhibit CYP3A4 and may increase exposure to temsirolimus and sirolimus. This could heighten mTOR-related toxicity.
How serious is the interaction between Temsirolimus and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity such as stomatitis, cytopenias, hyperglycemia and pneumonitis, and consider a dose reduction if adverse effects develop.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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