Drug interactions
Temsirolimus + Zafirlukast
Severity: Moderate
Temsirolimus and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so zafirlukast may raise exposure. This may increase mucositis, myelosuppression, hyperglycemia and hyperlipidemia.
What this interaction means in plain words
Temsirolimus and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Temsirolimus belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated temsirolimus and sirolimus metabolism by zafirlukast.
What to do
Monitor blood counts, glucose, lipids and mucosal toxicity. Consider an alternative to zafirlukast if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Temsirolimus with Zafirlukast?
MediHelp rates the interaction as moderate. Temsirolimus and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so zafirlukast may raise exposure. This may increase mucositis, myelosuppression, hyperglycemia and hyperlipidemia.
How serious is the interaction between Temsirolimus and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, glucose, lipids and mucosal toxicity. Consider an alternative to zafirlukast if toxicity emerges.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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