Drug interactions
Tepotinib + Tolvaptan
Severity: Moderate
Tepotinib and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and may increase exposure to tolvaptan, a P-gp substrate. This could intensify aquaresis and the risk of rapid sodium rise.
What this interaction means in plain words
Tepotinib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tepotinib belongs to Oncology; Tolvaptan belongs to Endocrine.
Why it happens
Inhibition of intestinal P-gp efflux increases tolvaptan absorption.
What to do
Monitor serum sodium and volume status closely, and reduce the tolvaptan dose if an exaggerated response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Tepotinib with Tolvaptan?
MediHelp rates the interaction as moderate. Tepotinib and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-gp and may increase exposure to tolvaptan, a P-gp substrate. This could intensify aquaresis and the risk of rapid sodium rise.
How serious is the interaction between Tepotinib and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and volume status closely, and reduce the tolvaptan dose if an exaggerated response occurs.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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