Drug interactions
Brentuximab + Tepotinib
Severity: Moderate
Brentuximab and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and raises exposure to P-gp substrates such as dabigatran. MMAE from brentuximab vedotin is a P-gp substrate, so higher exposure may increase neutropenia and neuropathy.
What this interaction means in plain words
Brentuximab and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
P-gp inhibition by tepotinib may raise MMAE exposure.
What to do
Monitor blood counts and neuropathy. Reduce or hold brentuximab vedotin if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brentuximab
- Bleomycin + Brentuximab Contraindicated
- Brentuximab + Dengue vaccine Major
- Brentuximab + Etrasimod Major
- Brentuximab + Idelalisib Major
- Brentuximab + Levoketoconazole Major
- Brentuximab + Nefazodone Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Brentuximab with Tepotinib?
MediHelp rates the interaction as moderate. Brentuximab and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and raises exposure to P-gp substrates such as dabigatran. MMAE from brentuximab vedotin is a P-gp substrate, so higher exposure may increase neutropenia and neuropathy.
How serious is the interaction between Brentuximab and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy. Reduce or hold brentuximab vedotin if toxicity develops.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
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