Drug interactions
Terbinafine + Trimipramine
Severity: Major
Terbinafine and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is metabolized in part by CYP2D6, so terbinafine can raise its levels. This increases the risk of sedation, anticholinergic effects, hypotension and cardiac conduction disturbances.
What this interaction means in plain words
Terbinafine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Terbinafine belongs to Anti Fungals; Trimipramine belongs to Central Nervous System.
Why it happens
Terbinafine inhibits CYP2D6, reducing trimipramine metabolism.
What to do
Monitor ECG and for tricyclic toxicity, and lower the trimipramine dose if needed. Prefer an alternative antifungal when possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Terbinafine with Trimipramine?
MediHelp rates the interaction as major. Terbinafine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trimipramine is metabolized in part by CYP2D6, so terbinafine can raise its levels. This increases the risk of sedation, anticholinergic effects, hypotension and cardiac conduction disturbances.
How serious is the interaction between Terbinafine and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for tricyclic toxicity, and lower the trimipramine dose if needed. Prefer an alternative antifungal when possible.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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