Drug interactions
Terbinafine + Valbenazine
Severity: Moderate
Terbinafine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of valbenazine is cleared partly by CYP2D6, and terbinafine can raise its exposure. This may increase somnolence and QT prolongation.
What this interaction means in plain words
Terbinafine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Terbinafine belongs to Anti Fungals; Valbenazine belongs to Central Nervous System.
Why it happens
Terbinafine inhibits CYP2D6, increasing active valbenazine metabolite levels.
What to do
Consider a reduced valbenazine dose and monitor for somnolence and QT prolongation, particularly in patients with cardiac risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Terbinafine with Valbenazine?
MediHelp rates the interaction as moderate. Terbinafine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The active metabolite of valbenazine is cleared partly by CYP2D6, and terbinafine can raise its exposure. This may increase somnolence and QT prolongation.
How serious is the interaction between Terbinafine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a reduced valbenazine dose and monitor for somnolence and QT prolongation, particularly in patients with cardiac risk.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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