Drug interactions
Terbinafine + Vortioxetine
Severity: Moderate
Terbinafine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine is primarily metabolized by CYP2D6, and CYP2D6 inhibitors increase its exposure. This may cause more nausea and other serotonergic adverse effects.
What this interaction means in plain words
Terbinafine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Terbinafine belongs to Anti Fungals; Vortioxetine belongs to Central Nervous System.
Why it happens
Terbinafine inhibits CYP2D6, decreasing vortioxetine clearance.
What to do
Monitor tolerability and consider reducing the vortioxetine dose by about half if a strong CYP2D6 inhibitor is added, per labeling for strong inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Terbinafine with Vortioxetine?
MediHelp rates the interaction as moderate. Terbinafine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine is primarily metabolized by CYP2D6, and CYP2D6 inhibitors increase its exposure. This may cause more nausea and other serotonergic adverse effects.
How serious is the interaction between Terbinafine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tolerability and consider reducing the vortioxetine dose by about half if a strong CYP2D6 inhibitor is added, per labeling for strong inhibitors.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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