Drug interactions
Terbinafine + Zileuton
Severity: Minor
Terbinafine and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine is cleared by several CYP enzymes, including CYP1A2, so zileuton could modestly raise its levels. Because no single pathway dominates, a clinically important rise is unlikely and the interaction is mostly theoretical.
What this interaction means in plain words
Terbinafine and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Terbinafine belongs to Anti Fungals; Zileuton belongs to Respiratory.
Why it happens
Zileuton may weakly reduce CYP1A2-mediated clearance of terbinafine, which has multiple redundant metabolic pathways.
What to do
No dose change is usually needed; watch for terbinafine adverse effects such as gastrointestinal upset or liver enzyme elevation during prolonged courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Terbinafine with Zileuton?
MediHelp rates the interaction as minor. Terbinafine and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Terbinafine is cleared by several CYP enzymes, including CYP1A2, so zileuton could modestly raise its levels. Because no single pathway dominates, a clinically important rise is unlikely and the interaction is mostly theoretical.
How serious is the interaction between Terbinafine and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for terbinafine adverse effects such as gastrointestinal upset or liver enzyme elevation during prolonged courses.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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