Drug interactions
Teriflunomide + Tretinoin
Severity: Moderate
Teriflunomide and Tretinoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tretinoin is partly metabolized by CYP2C8, which teriflunomide inhibits, so retinoid exposure may increase. Both drugs are teratogenic and can affect the liver.
What this interaction means in plain words
Teriflunomide and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Teriflunomide belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Inhibition of CYP2C8 by teriflunomide may reduce tretinoin clearance.
What to do
Monitor liver enzymes and retinoid toxicity, and maintain strict contraception for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Teriflunomide with Tretinoin?
MediHelp rates the interaction as moderate. Teriflunomide and Tretinoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tretinoin is partly metabolized by CYP2C8, which teriflunomide inhibits, so retinoid exposure may increase. Both drugs are teratogenic and can affect the liver.
How serious is the interaction between Teriflunomide and Tretinoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and retinoid toxicity, and maintain strict contraception for both drugs.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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