Drug interactions
Teriparatide + Zoledronic acid
Severity: Minor
Teriparatide and Zoledronic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriparatide stimulates bone formation while zoledronic acid suppresses bone turnover. Combining them has not been shown to give additional gains in bone density over teriparatide alone, and antiresorptives may blunt the anabolic response. There is no significant safety hazard.
What this interaction means in plain words
Teriparatide and Zoledronic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Teriparatide belongs to Musculoskeletal; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Pharmacodynamic opposition: antiresorptive action may blunt the anabolic effect of teriparatide.
What to do
Combination is generally not needed; use sequential therapy, typically an antiresorptive after the anabolic course, instead.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
Other interactions of Teriparatide
Frequently asked questions
Can I take Teriparatide with Zoledronic acid?
MediHelp rates the interaction as minor. Teriparatide and Zoledronic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriparatide stimulates bone formation while zoledronic acid suppresses bone turnover. Combining them has not been shown to give additional gains in bone density over teriparatide alone, and antiresorptives may blunt the anabolic response. There is no significant safety hazard.
How serious is the interaction between Teriparatide and Zoledronic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combination is generally not needed; use sequential therapy, typically an antiresorptive after the anabolic course, instead.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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