Drug interactions
Tetrabenazine + Trimipramine
Severity: Major
Tetrabenazine and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so the combination raises the risk of torsades de pointes. Tetrabenazine may also add to sedation and depressive symptoms.
What this interaction means in plain words
Tetrabenazine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tetrabenazine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Obtain an ECG before and during combined therapy and correct electrolytes. Tetrabenazine is also CYP2D6-dependent, so watch for CYP2D6-related interactions; consider alternatives if QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Tetrabenazine with Trimipramine?
MediHelp rates the interaction as major. Tetrabenazine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so the combination raises the risk of torsades de pointes. Tetrabenazine may also add to sedation and depressive symptoms.
How serious is the interaction between Tetrabenazine and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before and during combined therapy and correct electrolytes. Tetrabenazine is also CYP2D6-dependent, so watch for CYP2D6-related interactions; consider alternatives if QTc lengthens.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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