Drug interactions
Thioridazine + Tiotropium-olodaterol
Severity: Major
Thioridazine and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine markedly prolongs the QT interval and has anticholinergic activity. Olodaterol may add to arrhythmia risk through tachycardia and hypokalemia, and tiotropium may add modest anticholinergic effects.
What this interaction means in plain words
Thioridazine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Thioridazine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-induced hypokalemia, plus additive anticholinergic effects.
What to do
Avoid if possible; if used together, monitor ECG, potassium and magnesium, and watch for anticholinergic effects such as urinary retention and dry mouth.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Thioridazine with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Thioridazine and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thioridazine markedly prolongs the QT interval and has anticholinergic activity. Olodaterol may add to arrhythmia risk through tachycardia and hypokalemia, and tiotropium may add modest anticholinergic effects.
How serious is the interaction between Thioridazine and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used together, monitor ECG, potassium and magnesium, and watch for anticholinergic effects such as urinary retention and dry mouth.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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