Drug interactions
Thioridazine + Trimipramine
Severity: Contraindicated
Thioridazine and Trimipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Thioridazine also inhibits CYP2D6 and may raise tricyclic concentrations.
What this interaction means in plain words
Thioridazine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Thioridazine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with thioridazine inhibition of CYP2D6-mediated tricyclic metabolism.
What to do
Do not use together; choose an alternative antipsychotic or antidepressant with lower QT liability.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Thioridazine with Trimipramine?
MediHelp rates the interaction as contraindicated. Thioridazine and Trimipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Thioridazine also inhibits CYP2D6 and may raise tricyclic concentrations.
How serious is the interaction between Thioridazine and Trimipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative antipsychotic or antidepressant with lower QT liability.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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