Drug interactions
Tinidazole + Zileuton
Severity: Minor
Tinidazole and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tinidazole is partly metabolized by CYP3A4, and zileuton is only a weak inhibitor of this enzyme, so any rise in tinidazole exposure is expected to be small. Clinical significance is doubtful, and the pair is mostly a theoretical concern.
What this interaction means in plain words
Tinidazole and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tinidazole belongs to Anti Parasitic; Zileuton belongs to Respiratory.
Why it happens
Zileuton may weakly inhibit CYP3A4-mediated metabolism of tinidazole.
What to do
No routine adjustment is needed; be aware of possible increased gastrointestinal or neurological effects of tinidazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Tinidazole with Zileuton?
MediHelp rates the interaction as minor. Tinidazole and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tinidazole is partly metabolized by CYP3A4, and zileuton is only a weak inhibitor of this enzyme, so any rise in tinidazole exposure is expected to be small. Clinical significance is doubtful, and the pair is mostly a theoretical concern.
How serious is the interaction between Tinidazole and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; be aware of possible increased gastrointestinal or neurological effects of tinidazole.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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