Drug interactions
Tiotropium + Trimipramine
Severity: Moderate
Tiotropium and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with significant anticholinergic activity. With tiotropium it may cause additive dry mouth, constipation, urinary retention, blurred vision and tachycardia.
What this interaction means in plain words
Tiotropium and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tiotropium belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects and ask about urinary and visual symptoms. Use caution in narrow-angle glaucoma or prostatic hypertrophy and reduce the trimipramine dose if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Tiotropium with Trimipramine?
MediHelp rates the interaction as moderate. Tiotropium and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a tricyclic antidepressant with significant anticholinergic activity. With tiotropium it may cause additive dry mouth, constipation, urinary retention, blurred vision and tachycardia.
How serious is the interaction between Tiotropium and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and ask about urinary and visual symptoms. Use caution in narrow-angle glaucoma or prostatic hypertrophy and reduce the trimipramine dose if symptoms arise.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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