Drug interactions
Tipranavir + Upadacitinib
Severity: Moderate
Tipranavir and Upadacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir produces strong CYP3A4 inhibition and may increase upadacitinib exposure. This raises the risk of upadacitinib adverse effects such as serious infection.
What this interaction means in plain words
Tipranavir and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tipranavir belongs to Anti Virals; Upadacitinib belongs to Musculoskeletal.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, reducing upadacitinib metabolism.
What to do
Use the reduced upadacitinib dose advised for strong CYP3A4 inhibitors and monitor for infections and laboratory abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Tipranavir with Upadacitinib?
MediHelp rates the interaction as moderate. Tipranavir and Upadacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir given with ritonavir produces strong CYP3A4 inhibition and may increase upadacitinib exposure. This raises the risk of upadacitinib adverse effects such as serious infection.
How serious is the interaction between Tipranavir and Upadacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced upadacitinib dose advised for strong CYP3A4 inhibitors and monitor for infections and laboratory abnormalities.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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