Drug interactions
Tolbutamide + Trimipramine
Severity: Minor
Tolbutamide and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may modestly enhance the glucose-lowering effect of sulfonylureas and can mask or alter hypoglycemia symptoms. Clinically significant hypoglycemia is uncommon but possible.
What this interaction means in plain words
Tolbutamide and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tolbutamide belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on glucose regulation, possibly through altered insulin sensitivity.
What to do
Monitor blood glucose when trimipramine is started or stopped in patients taking tolbutamide. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Tolbutamide with Trimipramine?
MediHelp rates the interaction as minor. Tolbutamide and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may modestly enhance the glucose-lowering effect of sulfonylureas and can mask or alter hypoglycemia symptoms. Clinically significant hypoglycemia is uncommon but possible.
How serious is the interaction between Tolbutamide and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trimipramine is started or stopped in patients taking tolbutamide. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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