Drug interactions
Tolfenamic acid + Trazodone
Severity: Moderate
Tolfenamic acid and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone reduces platelet serotonin uptake and tolfenamic acid is an NSAID that inhibits platelet function and can damage the gastric mucosa. Together the risk of gastrointestinal bleeding rises.
What this interaction means in plain words
Tolfenamic acid and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolfenamic acid belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive impairment of platelet aggregation plus NSAID-induced mucosal injury.
What to do
Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest duration. Consider a proton pump inhibitor in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Tolfenamic acid with Trazodone?
MediHelp rates the interaction as moderate. Tolfenamic acid and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone reduces platelet serotonin uptake and tolfenamic acid is an NSAID that inhibits platelet function and can damage the gastric mucosa. Together the risk of gastrointestinal bleeding rises.
How serious is the interaction between Tolfenamic acid and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and use the lowest effective NSAID dose for the shortest duration. Consider a proton pump inhibitor in higher-risk patients.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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