Drug interactions
Trazodone + Verapamil
Severity: Moderate
Trazodone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil can raise trazodone concentrations, increasing sedation, orthostatic hypotension and potentially QT-related effects. Additive hypotension may also occur.
What this interaction means in plain words
Trazodone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trazodone belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, the main pathway forming trazodone's metabolite and clearing the parent drug.
What to do
Start trazodone at a low dose and titrate cautiously, monitoring for sedation, dizziness and hypotension. Reduce the trazodone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Verapamil?
MediHelp rates the interaction as moderate. Trazodone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil can raise trazodone concentrations, increasing sedation, orthostatic hypotension and potentially QT-related effects. Additive hypotension may also occur.
How serious is the interaction between Trazodone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trazodone at a low dose and titrate cautiously, monitoring for sedation, dizziness and hypotension. Reduce the trazodone dose if adverse effects appear.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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