Drug interactions
Trazodone + Zafirlukast
Severity: Minor
Trazodone and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is metabolized to its active metabolite by CYP3A4, which zafirlukast may weakly inhibit. A clinically important increase in sedation or hypotension is unlikely.
What this interaction means in plain words
Trazodone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Trazodone belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak CYP3A4 inhibition by zafirlukast reducing trazodone clearance.
What to do
No dose change is needed. Watch for excess sedation, dizziness or orthostatic hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Trazodone with Zafirlukast?
MediHelp rates the interaction as minor. Trazodone and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone is metabolized to its active metabolite by CYP3A4, which zafirlukast may weakly inhibit. A clinically important increase in sedation or hypotension is unlikely.
How serious is the interaction between Trazodone and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Watch for excess sedation, dizziness or orthostatic hypotension.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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