Drug interactions
Trimipramine + Umeclidinium-vilanterol
Severity: Major
Trimipramine and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, causing tachycardia and arrhythmias, and trimipramine also prolongs the QT interval. Trimipramine is also anticholinergic and may add to umeclidinium effects.
What this interaction means in plain words
Trimipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Trimipramine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Potentiation of adrenergic cardiovascular effects, additive QT prolongation and additive antimuscarinic activity.
What to do
Avoid if possible, particularly in patients with cardiac disease; if combined, monitor ECG, heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Trimipramine with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Trimipramine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-agonists, causing tachycardia and arrhythmias, and trimipramine also prolongs the QT interval. Trimipramine is also anticholinergic and may add to umeclidinium effects.
How serious is the interaction between Trimipramine and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, particularly in patients with cardiac disease; if combined, monitor ECG, heart rate and blood pressure.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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