Drug interactions
Tucatinib + Vincristine
Severity: Major
Tucatinib and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a CYP3A inhibitor and may raise vincristine exposure. Because vincristine has a narrow therapeutic index, higher levels may worsen neurotoxicity, including peripheral neuropathy, constipation or ileus, and autonomic effects.
What this interaction means in plain words
Tucatinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tucatinib belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4-mediated metabolism of vincristine, reducing its clearance.
What to do
Avoid the combination where an alternative exists. If it cannot be avoided, monitor closely for neurotoxicity and bowel dysfunction and consider reducing the vincristine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tucatinib with Vincristine?
MediHelp rates the interaction as major. Tucatinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib is a CYP3A inhibitor and may raise vincristine exposure. Because vincristine has a narrow therapeutic index, higher levels may worsen neurotoxicity, including peripheral neuropathy, constipation or ileus, and autonomic effects.
How serious is the interaction between Tucatinib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If it cannot be avoided, monitor closely for neurotoxicity and bowel dysfunction and consider reducing the vincristine dose.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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