Drug interactions
Tucatinib + Vinorelbine
Severity: Major
Tucatinib and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and may raise vinorelbine exposure. This may increase myelosuppression and neuropathy.
What this interaction means in plain words
Tucatinib and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Tucatinib belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing vinorelbine metabolism.
What to do
Avoid if possible; if used together, monitor neutrophil counts and neurotoxicity closely and consider reducing the vinorelbine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Tucatinib with Vinorelbine?
MediHelp rates the interaction as major. Tucatinib and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tucatinib is a moderate CYP3A inhibitor and may raise vinorelbine exposure. This may increase myelosuppression and neuropathy.
How serious is the interaction between Tucatinib and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used together, monitor neutrophil counts and neurotoxicity closely and consider reducing the vinorelbine dose.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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