Drug interactions
Umeclidinium-vilanterol + Valbenazine
Severity: Minor
Umeclidinium-vilanterol and Valbenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may prolong the QT interval at higher exposures, and vilanterol may also affect repolarization. Concurrent use may modestly raise arrhythmia risk in susceptible patients.
What this interaction means in plain words
Umeclidinium-vilanterol and Valbenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Umeclidinium-vilanterol belongs to Respiratory; Valbenazine belongs to Central Nervous System.
Why it happens
Possible additive effects on cardiac repolarization.
What to do
Obtain an ECG in patients with QT risk factors and correct electrolyte abnormalities. Be cautious when valbenazine exposure is increased by CYP inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Umeclidinium-vilanterol with Valbenazine?
MediHelp rates the interaction as minor. Umeclidinium-vilanterol and Valbenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valbenazine may prolong the QT interval at higher exposures, and vilanterol may also affect repolarization. Concurrent use may modestly raise arrhythmia risk in susceptible patients.
How serious is the interaction between Umeclidinium-vilanterol and Valbenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG in patients with QT risk factors and correct electrolyte abnormalities. Be cautious when valbenazine exposure is increased by CYP inhibitors.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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