Drug interactions
Upadacitinib + Voriconazole
Severity: Moderate
Upadacitinib and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole is a strong CYP3A4 inhibitor and increases upadacitinib exposure. This raises the risk of dose-related adverse effects such as infection, particularly relevant in a patient already on antifungal therapy.
What this interaction means in plain words
Upadacitinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Upadacitinib belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of upadacitinib.
What to do
Follow labeling, which recommends a reduced upadacitinib dose with strong CYP3A4 inhibitors. Monitor for infections and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Upadacitinib with Voriconazole?
MediHelp rates the interaction as moderate. Upadacitinib and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole is a strong CYP3A4 inhibitor and increases upadacitinib exposure. This raises the risk of dose-related adverse effects such as infection, particularly relevant in a patient already on antifungal therapy.
How serious is the interaction between Upadacitinib and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow labeling, which recommends a reduced upadacitinib dose with strong CYP3A4 inhibitors. Monitor for infections and other adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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