Drug interactions
Vadadustat + Zidovudine
Severity: Moderate
Vadadustat and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat may increase exposure to zidovudine, which is eliminated partly via renal organic anion transport. Higher zidovudine levels could worsen anaemia, neutropenia and other dose-related toxicity.
What this interaction means in plain words
Vadadustat and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vadadustat belongs to Endocrine; Zidovudine belongs to Anti Virals.
Why it happens
Vadadustat inhibits OAT3 renal transporters, reducing the tubular secretion of zidovudine.
What to do
Monitor blood counts and signs of zidovudine toxicity, and consider reducing the zidovudine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Vadadustat with Zidovudine?
MediHelp rates the interaction as moderate. Vadadustat and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat may increase exposure to zidovudine, which is eliminated partly via renal organic anion transport. Higher zidovudine levels could worsen anaemia, neutropenia and other dose-related toxicity.
How serious is the interaction between Vadadustat and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of zidovudine toxicity, and consider reducing the zidovudine dose if adverse effects emerge.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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