Drug interactions
Velpatasvir + Voriconazole
Severity: Minor
Velpatasvir and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may modestly increase velpatasvir exposure as CYP3A4 contributes to its metabolism. The effect is small and rarely clinically significant.
What this interaction means in plain words
Velpatasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Velpatasvir belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, a minor elimination pathway for velpatasvir.
What to do
No dose adjustment is generally required; monitor for common adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Velpatasvir and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
Frequently asked questions
Can I take Velpatasvir with Voriconazole?
MediHelp rates the interaction as minor. Velpatasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may modestly increase velpatasvir exposure as CYP3A4 contributes to its metabolism. The effect is small and rarely clinically significant.
How serious is the interaction between Velpatasvir and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for common adverse effects such as headache and fatigue.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
