Drug interactions
Vemurafenib + Voriconazole
Severity: Major
Vemurafenib and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Voriconazole may also increase vemurafenib exposure through CYP3A4 inhibition.
What this interaction means in plain words
Vemurafenib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Vemurafenib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation and CYP3A4 inhibition by voriconazole.
What to do
Avoid if possible. If used, monitor ECG and electrolytes at baseline and regularly during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Vemurafenib with Voriconazole?
MediHelp rates the interaction as major. Vemurafenib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use raises the risk of torsades de pointes. Voriconazole may also increase vemurafenib exposure through CYP3A4 inhibition.
How serious is the interaction between Vemurafenib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, monitor ECG and electrolytes at baseline and regularly during treatment.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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