Drug interactions
Verapamil + Vortioxetine
Severity: Minor
Verapamil and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clinically meaningful interaction is established between verapamil and vortioxetine. Vortioxetine is mainly metabolized by CYP2D6, and verapamil is not a significant inhibitor of it. Any added serotonergic effect is not expected from verapamil.
What this interaction means in plain words
Verapamil and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Verapamil belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
No established mechanism; verapamil has no relevant serotonergic activity and only minor effects on vortioxetine's metabolic pathways.
What to do
No specific adjustment is needed; monitor for general vortioxetine adverse effects such as nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Verapamil with Vortioxetine?
MediHelp rates the interaction as minor. Verapamil and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clinically meaningful interaction is established between verapamil and vortioxetine. Vortioxetine is mainly metabolized by CYP2D6, and verapamil is not a significant inhibitor of it. Any added serotonergic effect is not expected from verapamil.
How serious is the interaction between Verapamil and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed; monitor for general vortioxetine adverse effects such as nausea.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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