Drug interactions
Verapamil + Zonisamide
Severity: Minor
Verapamil and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly metabolised by CYP3A4, so verapamil could raise its concentrations somewhat. The clinical impact is probably small and not well documented.
What this interaction means in plain words
Verapamil and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Verapamil belongs to Cardiovascular; Zonisamide belongs to Central Nervous System.
Why it happens
Verapamil may modestly inhibit CYP3A4-mediated metabolism of zonisamide.
What to do
No routine adjustment is needed. Watch for somnolence, dizziness or other zonisamide adverse effects after verapamil is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Verapamil with Zonisamide?
MediHelp rates the interaction as minor. Verapamil and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is partly metabolised by CYP3A4, so verapamil could raise its concentrations somewhat. The clinical impact is probably small and not well documented.
How serious is the interaction between Verapamil and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for somnolence, dizziness or other zonisamide adverse effects after verapamil is started.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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