Drug interactions
Vortioxetine + Warfarin
Severity: Moderate
Vortioxetine and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine inhibits serotonin reuptake and may increase bleeding risk when combined with warfarin. Its labeling notes this risk with anticoagulants.
What this interaction means in plain words
Vortioxetine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Vortioxetine belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Impaired platelet serotonin uptake and function adds to warfarin anticoagulation.
What to do
Monitor INR when starting or stopping vortioxetine and counsel patients on bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Vortioxetine with Warfarin?
MediHelp rates the interaction as moderate. Vortioxetine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine inhibits serotonin reuptake and may increase bleeding risk when combined with warfarin. Its labeling notes this risk with anticoagulants.
How serious is the interaction between Vortioxetine and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR when starting or stopping vortioxetine and counsel patients on bleeding signs.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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