Drug interactions
Voxelotor + Zonisamide
Severity: Moderate
Voxelotor and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and raise exposure to sensitive substrates. Zonisamide is partly CYP3A4-metabolized, so higher levels with more CNS adverse effects are possible.
What this interaction means in plain words
Voxelotor and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Voxelotor belongs to Miscellaneous; Zonisamide belongs to Central Nervous System.
Why it happens
Voxelotor inhibits CYP3A4, decreasing zonisamide metabolism.
What to do
Monitor for sedation, dizziness and other zonisamide adverse effects, reducing the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Voxelotor and Zonisamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Voxelotor with Zonisamide?
MediHelp rates the interaction as moderate. Voxelotor and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can inhibit CYP3A4 and raise exposure to sensitive substrates. Zonisamide is partly CYP3A4-metabolized, so higher levels with more CNS adverse effects are possible.
How serious is the interaction between Voxelotor and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and other zonisamide adverse effects, reducing the dose if needed.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
