Drug interactions
Zafirlukast + Zonisamide
Severity: Minor
Zafirlukast and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is metabolised partly by CYP3A4, which zafirlukast may weakly inhibit. A meaningful rise in zonisamide levels is unlikely.
What this interaction means in plain words
Zafirlukast and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Zafirlukast belongs to Respiratory; Zonisamide belongs to Central Nervous System.
Why it happens
Theoretical weak CYP3A4 inhibition by zafirlukast reducing zonisamide clearance.
What to do
No routine adjustment is needed. Monitor for somnolence, dizziness or other zonisamide adverse effects if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Zafirlukast with Zonisamide?
MediHelp rates the interaction as minor. Zafirlukast and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is metabolised partly by CYP3A4, which zafirlukast may weakly inhibit. A meaningful rise in zonisamide levels is unlikely.
How serious is the interaction between Zafirlukast and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for somnolence, dizziness or other zonisamide adverse effects if symptoms appear.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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