تداخلهای دارویی
Allopurinol + Valoctocogene roxaparvovec
شدت: متوسط
Allopurinol and Valoctocogene roxaparvovec: moderate interaction.
آخرین بهروزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes ALT elevations. Hepatotoxic drugs, including allopurinol which can occasionally cause hepatitis, may increase the risk of liver injury and confound interpretation of enzyme rises.
معنای این تداخل به زبان ساده
Allopurinol and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Valoctocogene roxaparvovec belongs to Miscellaneous.
چرا رخ میدهد
Additive hepatotoxic potential in a liver transduced by AAV gene therapy; no pharmacokinetic mechanism is established.
اقدام لازم
Monitor ALT regularly after infusion as per product labeling and review necessity of allopurinol. Consider alternatives if liver enzymes rise.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Allopurinol و Valoctocogene roxaparvovec، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Allopurinol
تداخلات دیگر Valoctocogene roxaparvovec
پرسشهای متداول
Can I take Allopurinol with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Allopurinol and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly causes ALT elevations. Hepatotoxic drugs, including allopurinol which can occasionally cause hepatitis, may increase the risk of liver injury and confound interpretation of enzyme rises.
How serious is the interaction between Allopurinol and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT regularly after infusion as per product labeling and review necessity of allopurinol. Consider alternatives if liver enzymes rise.
What other medicines interact with Allopurinol?
MediHelp also lists interactions of Allopurinol with, for example, Azathioprine, Didanosine, Mercaptopurine. The full list is on the Allopurinol page.
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