تداخل‌های دارویی
Dantrolene + Valoctocogene roxaparvovec
شدت: شدید
Dantrolene and Valoctocogene roxaparvovec: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly raises liver enzymes. Dantrolene, particularly with long-term use, can cause serious hepatotoxicity, so combined use may add to liver injury or confound its assessment.
معنای این تداخل به زبان ساده
Dantrolene and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dantrolene belongs to Musculoskeletal; Valoctocogene roxaparvovec belongs to Miscellaneous.
چرا رخ می‌دهد
Additive hepatotoxicity from a hepatotoxic drug and a liver-targeted gene therapy.
اقدام لازم
Monitor liver enzymes closely and consider alternative antispasticity therapy if dantrolene is not essential. Stop dantrolene if transaminases rise significantly.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dantrolene و Valoctocogene roxaparvovec، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Dantrolene
تداخلات دیگر Valoctocogene roxaparvovec
پرسش‌های متداول
Can I take Dantrolene with Valoctocogene roxaparvovec?
MediHelp rates the interaction as major. Dantrolene and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly raises liver enzymes. Dantrolene, particularly with long-term use, can cause serious hepatotoxicity, so combined use may add to liver injury or confound its assessment.
How serious is the interaction between Dantrolene and Valoctocogene roxaparvovec?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and consider alternative antispasticity therapy if dantrolene is not essential. Stop dantrolene if transaminases rise significantly.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
