Interactions médicamenteuses
Caplacizumab + Edoxaban
Gravité: Majeure
Caplacizumab and Edoxaban: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Caplacizumab blocks von Willebrand factor-mediated platelet adhesion and increases bleeding tendency. With edoxaban, the risk of serious bleeding is further increased.
Ce que signifie cette interaction, en termes simples
Caplacizumab and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caplacizumab belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Pourquoi elle survient
Additive hemostatic impairment from anti-vWF antiplatelet activity and factor Xa inhibition.
Conduite à tenir
Consider holding edoxaban during caplacizumab therapy unless a strong indication exists. If both are continued, monitor for bleeding and hemoglobin closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Caplacizumab et Edoxaban, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Edoxaban
- Apixaban + Edoxaban Contre-indiquée
- Defibrotide + Edoxaban Contre-indiquée
- Edoxaban + Ketorolac Contre-indiquée
- Abciximab + Edoxaban Majeure
- Acetylsalicylic acid + Edoxaban Majeure
- Argatroban + Edoxaban Majeure
Autres interactions de Caplacizumab
- Abciximab + Caplacizumab Majeure
- Acetylsalicylic acid + Caplacizumab Majeure
- Alteplase + Caplacizumab Majeure
- Anagrelide + Caplacizumab Majeure
- Apixaban + Caplacizumab Majeure
- Argatroban + Caplacizumab Majeure
Questions fréquentes
Can I take Caplacizumab with Edoxaban?
MediHelp rates the interaction as major. Caplacizumab and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-mediated platelet adhesion and increases bleeding tendency. With edoxaban, the risk of serious bleeding is further increased.
How serious is the interaction between Caplacizumab and Edoxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding edoxaban during caplacizumab therapy unless a strong indication exists. If both are continued, monitor for bleeding and hemoglobin closely.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
