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Interactions médicamenteuses

Colesevelam + Liothyronine

Gravité: Modérée

Colesevelam and Liothyronine: moderate interaction.

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Résumé

Colesevelam can bind oral thyroid hormones in the gut and reduce their absorption. This may lead to raised TSH and hypothyroid symptoms in patients on replacement.

Ce que signifie cette interaction, en termes simples

Colesevelam and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Colesevelam belongs to Endocrine; Liothyronine belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Resin binding of thyroid hormone in the gastrointestinal tract decreases absorption.

Conduite à tenir

Give liothyronine at least 4 hours before colesevelam and monitor TSH after starting or changing colesevelam.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Colesevelam with Liothyronine?

MediHelp rates the interaction as moderate. Colesevelam and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind oral thyroid hormones in the gut and reduce their absorption. This may lead to raised TSH and hypothyroid symptoms in patients on replacement.

How serious is the interaction between Colesevelam and Liothyronine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give liothyronine at least 4 hours before colesevelam and monitor TSH after starting or changing colesevelam.

What other medicines interact with Colesevelam?

MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.

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