Référentiel des médicaments
Ticlopidine
Ticlopidine is a medicine in the class cardiovascular. It is used for coronary artery stent thrombosis.
- Classe médicamenteuse: Cardiovascular
- Indications: coronary artery stent thrombosis
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Formes courantes
- comprimé
- Dosages courants
- 250 mg
- Interactions connues
- 113 (Contre-indiquée: 1 · Majeure: 32 · Modérée: 52 · Mineure: 28)
- Noms commerciaux
- 3
- Pays et marchés
- 2
Indications
Mécanisme d'action
Platelet aggregation inhibitor; reversibly interacts with the platelet P2Y12 ADP-receptor to prevent signal transduction and platelet activation
Posologie adulte habituelle (résumé de la notice)
Stroke: 250 mg PO q12hr with food
Grossesse et allaitement
- Grossesse
- Unknown Largely withdrawn (blood disorders); clopidogrel has replaced it. Animal studies at high doses showed no birth defects; human data are very limited. Avoid in pregnancy; if an antiplatelet is needed, clopidogrel or low-dose aspirin is preferred.
- Allaitement
- Unknown Not known if it passes into milk; no LactMed record. The old US label advised stopping the drug or nursing. Because of its serious blood side effects (neutropenia, TTP), avoid while breastfeeding and use an alternative.
Effets indésirables signalés
- Diarrhea
- Nausea
- Rash
- Dyspepsia
- Elevated alkaline phosphatase
Mises en garde encadrées
- May cause life-threatening hematologic events, including neutropenia, agranulocytosis, thrombocytopenia purpura, and aplastic anemia
Contre-indications
- Neutropenia, thrombocytopenia, hemostatic disorder or active bleeding (GI bleed, ICH), severe hepatic impairment, history of either thrombotic thrombocytopenic purpura (TTP) or aplastic anemia
- Current use of other anticoagulant drugs
Précautions particulières
- Increases serum chlesterol & triglyceride concentrations
- Patients with lesions that have a propensity to bleed
- Due to risk of adverse hematologic events, for stroke prevention use only in ASA-intolerant patients
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (113)
- Mavacamten + Ticlopidine Contraindicated
- Abrocitinib + Ticlopidine Major
- Acetylsalicylic acid + Ticlopidine Major
- Apixaban + Ticlopidine Major
- Aspirin + Ticlopidine Major
- Aspirin / citric acid / sodium bicarbonate + Ticlopidine Major
- Aspirin rectal + Ticlopidine Major
- Betrixaban + Ticlopidine Major
- Carbamazepine + Ticlopidine Major
- Cilostazol + Ticlopidine Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Ticlopidine used for?
Ticlopidine is a medicine in the class cardiovascular. It is used for Coronary artery stent thrombosis, Stroke.
What side effects have been reported with Ticlopidine?
Diarrhea, Nausea, Rash, Dyspepsia, Elevated alkaline phosphatase. Serious warning: May cause life-threatening hematologic events, including neutropenia, agranulocytosis, thrombocytopenia purpura, and aplastic anemia
Can Ticlopidine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Largely withdrawn (blood disorders); clopidogrel has replaced it. Animal studies at high doses showed no birth defects; human data are very limited. Avoid in pregnancy; if an antiplatelet is needed, clopidogrel or low-dose aspirin is preferred. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed record. The old US label advised stopping the drug or nursing. Because of its serious blood side effects (neutropenia, TTP), avoid while breastfeeding and use an alternative.
What does Ticlopidine interact with?
MediHelp lists 113 known interactions for Ticlopidine. Contraindicated: 1 · Major: 32 · Moderate: 52 · Minor: 28. The most serious include Mavacamten, Abrocitinib, Acetylsalicylic acid.
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