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Interactions médicamenteuses

Apixaban + Ticlopidine

Gravité: Majeure

Apixaban and Ticlopidine: major interaction.

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Résumé

Ticlopidine is a potent antiplatelet drug and adds to apixaban's bleeding risk. Ticlopidine also carries hematologic toxicity, further complicating bleeding assessment.

Ce que signifie cette interaction, en termes simples

Apixaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apixaban belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive effects of P2Y12 receptor blockade and factor Xa inhibition.

Conduite à tenir

Avoid if possible; clopidogrel is generally preferred when an antiplatelet is needed. If combined, monitor for bleeding and blood counts.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apixaban with Ticlopidine?

MediHelp rates the interaction as major. Apixaban and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine is a potent antiplatelet drug and adds to apixaban's bleeding risk. Ticlopidine also carries hematologic toxicity, further complicating bleeding assessment.

How serious is the interaction between Apixaban and Ticlopidine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; clopidogrel is generally preferred when an antiplatelet is needed. If combined, monitor for bleeding and blood counts.

What other medicines interact with Apixaban?

MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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